Reserveratol, the now-famous chemical is red wine, turns out to remain effective against cancer even after the body converts it into other compounds. That is the encouraging finding of research done at the University of Leicester in the UK and published in the journal Science Translational Medicine.
A release from the university notes that this is an important discovery because resveratrol is metabolized very quickly. Scientists had previously been thought that levels of the extracted chemical drop too quickly to make it usable in clinical trials. However, the new research shows that the chemical can still be taken into cells after it has been metabolized into resveratrol sulfates. Enzymes within cells are then able to break it down into resveratrol again, meaning that levels of resveratrol in the cells are higher than was previously thought. In fact, the results appear to show resveratrol may be more effective once it has been generated from resveratrol sulfate than it is if it has never been metabolized because the concentrations achieved are higher.
The team, led by University of Leicester translational cancer research expert Professor Karen Brown, administered resveratrol sulfate to mice models. The researchers were subsequently able to detect free resveratrol in plasma and a variety of tissues in the mice.
This is the first direct sign that resveratrol can be formed from resveratrol sulfate in live animals, and the researchers think it may help to show how resveratrol is able to have beneficial effects in animals.
The study also showed that resveratrol generated from resveratrol sulfate is able to slow the growth of cancer cells by causing them to digest their own internal constituents and stopping them from dividing.
The release quotes Professor Brown as saying, "There is a lot of strong evidence from laboratory models that resveratrol can do a whole host of beneficial things – from protecting against a variety of cancers and heart disease to extending lifespan. It has been known for many years that resveratrol is rapidly converted to sulfate and glucuronide metabolites in humans and animals – meaning the plasma concentrations of resveratrol itself quickly become very low after administration. It has always been difficult to understand how resveratrol is able to have activity in animal models when the concentrations present are so low, and it has made some people skeptical about whether it might have any effects in humans. Researchers have hypothesized for a long time that resveratrol might be regenerated from its major metabolites in whole animals but it has never been proven. Our study was the first to show that resveratrol can be regenerated from sulfate metabolites in cells and that this resveratrol can then have biological activity that could be useful in a wide variety of diseases in humans.
Dzobak Volodymyr
РОЗДУМИ ПРО НАДВАЖЛИВЕ або ЧОМУ НАШІ ОЛІГАРХИ СТАЛИ МОГИЛЬЩИКАМИ НИНІШНЬОЇ УКРАЇНИ
